The NFL kicks off Week 6 in a few hours, with the New England Patriots hosting the New York Giants on Thursday Night Football. The matchup features a host of fantasy football options, and six weeks into the season, a whole host of injury issues to figure out. The Giants have ruled out Saquon Barkley, Wayne Gallman, Evan Engram, and Sterling Shepard. The Patriots have listed Rex Burkhead, Josh Gordon, and Julian Edelman as questionable.

Inactives are due at 6:50 p.m., but there will be news earlier in the day as we prepare for the game. If you’re trying to figure out your fantasy football lineups, this information is critical to getting the right players in the right spots. There’s plenty of time for the rest of your fantasy lineups, but many of us have some last minutes decisions to make on Thursday evening.

We’ll provide updates on injuries, key start/sit decisions, and more leading up to the 8:20 p.m. kickoff.

Rex Burkhead inactive, Julian Edelman, Josh Gordon active

The Patriots released their Week 6 inactive report, and there are no surprises. As reported earlier today, running back Rex Burkhead is inactive due to his foot injury. Look for Sony Michel to have a chance at a monster evening, while James White is in line for even more work in the passing game. Wide receivers Julian Edelman and Josh Gordon are both active for the game, and should be in line for big opportunities against a bad Giants defense.

Rex Burkhead not expected to play

The New England Patriots are not expected to have running back Rex Burkhead in the lineup Thursday evening, according to ESPN’s Adam Schefter. Burkhead missed last week’s game with a foot injury and was listed as limited on all three practice participation reports this week. He was designated as questionable, but it appears he will not play. Sony Michel remains the team’s starting running back, while James White serves primarily in the passing game. White could see some additional rushing attempts with Burkhead sidelined. Both Michel and White are strong starts, although White is significantly stronger in PPR leagues.