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Point spread, total, money line, injury report and more for Rams-49ers in Week 16

Goff vs. Garoppolo. Which quarterback will come out in top in this battle for California? We break down notable odds, including the point spread, trends, and ATS history.

San Francisco 49ers quarterback Jimmy Garoppolo throws a pass against the Los Angeles Rams during the first half at Los Angeles Memorial Coliseum. Orlando Ramirez-USA TODAY Sports

Saturday night ends with an NFC West matchup between the two California teams. The Los Angeles Rams look to cling on to what little playoff hopes they have left after failing to beat (or even come close to) the Dallas Cowboys last week. Meanwhile, the San Francisco 49ers aim to get back to the top of the division after getting stunned by the Falcons in the final seconds of the game. The Niners won their last meeting against the Rams 20-7 earlier this season, making them strong favorites in the second tilt.

The way to attack these defenses is typically on the ground, though recently the Niners have been susceptible in the air, as well. For two consecutive weeks, a wide receiver (Michael Thomas and Julio Jones) has posted exactly 134 receiving yards against SF’s defense. Cooper Kupp (DFS salary $6,600) is the most likely candidate to achieve that number this week, as he’s gone for over 100 receiving yards in five games this season. Although, Jared Goff ($5,800) hasn’t been connecting with his top receiver in that capacity since October.

If we’re looking at the hot hands, all signs point to this being a tight end battle. Tyler Higbee ($5,000) has absolutely erupted after the Rams lost Gerald Everett to injury. The fourth-year tight end now has a three-game 100+ receiving yard streak. If Everett remains sidelined, watch for Higbee to draw his weekly share of 8-12 targets. On the other side, we have one of the league’s best tight ends, George Kittle ($6,500). He has the second-highest average of yards per game (74) and is coming off a week where he reeled in a career-high 13 catches for 134 yards. Don’t be surprised to see both tight ends get a lot of usage in this one. Ultimately, I’m picking the Niners to get the best of the Rams with the point total hitting the over.

All odds provided by DraftKings Sportsbook and all odds subject to change.

Rams at 49ers

Betting Odds

Point Spread: Rams +6.5
Total Points: 45
Money Line: Rams +220; 49ers -275


Overall: Rams 8-6; 49ers 11-3
ATS: Rams 9-5; 49ers 9-5
O/U: Rams 5-9; 49ers 7-7

Injury Report


Doubtful: CB Troy Hill (thumb)

Questionable: K Greg Zuerlein (right quadricep)


Out: DE Dee Ford (quadricep, hamstring), S Jaquiski Tartt (ribs), DT Jullian Taylor (elbow)

Questionable: G Mike Person (neck)

Betting Trends

  • The 49ers have won each of their last eight December home games against NFC West opponents.
  • The Rams have covered the spread in each of their last eight road games following a loss.
  • Sixteen of the Rams’ last 20 road games in December have gone UNDER the total points line.

Odds and lines subject to change. See website for actual odds.
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