The 49ers will play their next two home games in Arizona because of Covid-19 regulations in their home county of Santa Clara, so they won’t play at Levis’s Stadium until their Week 17 matchup against the Seattle Seahawks. They managed to upset the Los Angeles Rams following the return of Deebo Samuel and could continue to gain momentum against a Buffalo defense that’s struggled all year. The Bills have won won four of their last five games despite inconsistent play from Josh Allen and could have a hard time against a San Francisco defense that’s shut down the passing game of opposing teams despite not having Richard Sherman and key members of the defensive line for most of the year.
If you can’t watch this game on TV, you have the option to stream the matchup via WatchESPN. If you don’t have cable, you can get a free trial from YouTube TV, Hulu with Live TV, AT&T TV Now, FuboTV, or Sling TV to stream Monday Night Football this week.
The game is often a little bit delayed on live streams, but usually it’s only between 30 and 60 seconds behind the TV broadcast. That can impact you if you’re on Twitter during the game, but otherwise it’s an easy option.
The Bills opened as 1.5-point favorites and -124 on the moneyline but are now one-point underdogs and +100 on the money line. The 49ers opened at +110, but are now -114. The point total opened 48 and now sits at 47.