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How the public is betting Bills vs. 49ers on Monday Night Football in Week 13

The 49ers host the Bills in Arizona for Week 13 Monday Night Football. We discuss how the public is picking this one.

A general view of gameplay during the first half between the Buffalo Bills and the Arizona Cardinals at State Farm Stadium on November 15, 2020 in Glendale, Arizona. Photo by Christian Petersen/Getty Images

The NFL has a Monday doubleheader this week due to Steelers-Washington getting pushed back a day, and the evening wraps with Bills vs. 49ers in the Monday Night Football slot. The game kicks off at 8:15 p.m. ET and will be simulcast on ESPN and ABC.

The 49ers are the hosts for this game, but it is taking place in Glendale, Arizona at the Cardinals’ State Farm Stadium. Santa Clara county, home of the 49ers’ Levi’s Stadium, implemented a lockdown that will prevent the 49ers from playing home games for the next two weeks. They could return for their regular season finale in January, but that is up in the air.

With all that being said, where are the bettors placing their money as we get closer to game time? Let’s check it out below! All the odds and info were provided by DraftKings Sportsbook.

Point Spread

The Bills opened as three-point favorites, but this line has swung wildly and a few hours before kickoff, the 49ers are 1.5-point favorites. The 49ers were getting early money, but as of game day, 75 percent of handle and 76 percent of bets are on the Bills.

Is the public right? The reverse line movement is fascinating for this one. The 49ers have gotten healthier, but Nick Mullens is still the quarterback. The Bills are leading the AFC East, but have had some ups and downs. I’m inclined to stick with the public, particularly with the line now favoring the 49ers, but that movement is fascinating.


The point total opened at 48, slipped to 47, and currently sits at 47.5. 75 percent of handle and 72 percent of bets are on the over.

Is the public right? This game features the 9th-ranked 49ers defense and the 16th-ranked Bills defense. The Bills are scoring 27.2 points per game while the 49ers are scoring 23.7 points per game for the season and 22.6 in Mullens’ six starts. It’s notable the 49ers backfield is fully healthy for the first time in a while and they’ll have both Deebo Samuel and Brandon Aiyuk available. I’d stay away from the point total, but if I had to pick a side, it’d be the slightest of leans under.


The Bills opened as -136 favorites but are now +106 underdogs, while the 49ers opened as +112 underdogs and are now -121 favorites. 83 percent of handle and 85 percent of bets is on the Bills.

Is the public right? It’s similar to the point spread discussion. The oddsmaker thinks the 49ers deserve more respect than bettors are giving them. I’m a 49ers fan and my big hang-up is that Nick Mullens is inconsistent. The 49ers biggest opportunity is that Buffalo’s defense ranks 22nd in run defense efficiency. I think Buffalo probably wins this, but if the 49ers can get going on the ground, they could very much win this one.

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