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Raheem Mostert injures knee in Week 2, will miss Week 3

The 49ers lost running back Jerick McKinnon to a knee injury in Week 2. We break down what it means.

San Francisco 49ers running back Raheem Mostert (31) rushes for a touchdown during the first quarter against the New York Jetsat MetLife Stadium.  Vincent Carchietta-USA TODAY Sports

Tuesday update: Mostert underwent an MRI on his knee and it confirmed an MCL sprain, according to Tom Pelissero. There is reportedly “optimism it won’t lead to an extended absence.” Mostert will not play in Week 3, but will be worth tracking in Week 4.

Monday update: Kyle Shanahan told the media Mostert has an MCL sprain and will not play in Week 3. He also said Tevin Coleman has a knee sprain and they’re checking his MRI results to determine the damage.

Post-game update: While Nick Bosa is done for the year with his knee injury, Raheem Mostert likely will not miss nearly as much time. Jason La Canfora is reporting the team is looking at his MCL not his ACL. That could mean a few weeks absence, but likely means it would not be season-ending. Tevin Coleman got hurt as well, so Jerick McKinnon is the player to watch.

San Francisco 49ers running back Raheem Mostert is OUT. Wow. This day just keeps getting worse for injuries across the NFL and the 49ers are unfortunately a recipient of two big ones with QB Jimmy Garoppolo and starting RB Moster out. Mostert hurt his knee and will not return. Tevin Coleman and Jerick McKinnon will see an uptick in work.