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Opening Week 12 Bills vs. Saints odds plus early movement

We’ve got an early look at the DraftKings Sportsbook betting lines for the Buffalo Bills and New Orleans Saints Week 12 matchup as the NFL wraps up Week 11.

Quarterback Josh Allen #17 of the Buffalo Bills leads his team off the field after warm-ups before the start of the game against the Jacksonville Jaguars at TIAA Bank Field on November 7, 2021 in Jacksonville, Florida. The Jaguars defeated the Bills 9 to 6 Photo by Don Juan Moore/Getty Images

The NFL is wrapping up its Week 11 Sunday slate and Sunday Night Football and Monday Night Football remain. In the meantime, we’ve got some early odds to get you ready for Week 12. The Buffalo Bills and New Orleans Saints will face off this coming week, with kickoff set for 8:20 p.m. ET on Thanksgiving.

The Bills took a big L against the Indianapolis Colts in Week 11 as they lost 41-15. The Saints didn’t fare much better against the Philadelphia Eagles as they lost 40-29.

DraftKings Sportsbook posted opening odds for this matchup earlier this week. Here’s a look at what the odds opened at and where they re-opened at the Bills-Saints Week 12 matchup.

Bills vs. Saints

Re-opened point spread: Bills -4.5
Point total: 46.5
Moneyline: Bills -210, Saints +175

Opening point spread: Bills -4.5
Opening point total: 47.5

Early pick: BUF -4.5

In the week after the three games that the Bills lost previously this season, they responded with a win. Even though the Saints will theoretically have running back Alvin Kamara back, the rest of the offense has been shaky. The Bills gave up five total touchdowns to running back Jonathan Taylor, but they still have one of the best defenses in the NFL. On a short week, they will make the adjustments needed to stop the Saints' offense and reignite their own to cover.

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