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Colts vs. Titans game picks, best bets for Week 3 NFL season

We take a look at the best bets available for the Indianapolis Colts-Tennessee Titans Week 3 matchup available on DraftKings Sportsbook, including our favorite player prop.

Derrick Henry #22 of the Tennessee Titans carries the ball during the third quarter against the Seattle Seahawks at Lumen Field on September 19, 2021 in Seattle, Washington. Photo by Steph Chambers/Getty Images

Sunday’s AFC South showdown between the Indianapolis Colts and the Tennessee Titans will be a battle of two teams already seemingly headed in opposite directions. The game will kick off at 1 p.m. ET on CBS.

Here, we’ll take a look at our picks for best bets for TEAM vs. TEAM in Week 3 of the NFL season. Odds come via DraftKings Sportsbook.

Colts vs. Titans Week 3 odds

Spread: Titans -5
Point total: 48
Moneyline: Titans -255, Colts +205

Our picks for Colts vs. Titans

Pick against the spread: Titans -5

The Titans shook off a horrible Week 1 loss to Arizona with an impressive come-from-behind overtime victory over the Seattle Seahawks last Sunday. Combine this with Carson Wentz being doubtful for Sunday and Tennessee could cover here with ease.

Over/under 48 points: U48

With the possibility of Jacob Eason and Brett Hundley possibly taking snaps for Indy, one can’t imagine that offense holding up it’s end of the stick to trigger the over here. U48 sounds good with the Titans doing most of the scoring.

Preferred player prop: TBD

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