Watch out, Doctor Strange: Multiverse of Madness. Avatar: The Way of Water is coming for the biggest 2022 opening crown. Director James Cameron’s sequel to his highest-grossing movie of all time, 2009’s Avatar, is currently tracking to bring in $150-175 million domestically and $450-$550 million at the worldwide box office – according to Deadline. This would be Multiverse of Madness which opened with a $449 million worldwide gross earlier this year. It would also beat Spider-Man: No Way Home’s $320 million overseas gross last December. Disney is opening the film with its widest global release ever with 52,000 screens. The film is opening right at the peak of the holiday season with films such as Puss In Boots: The Last Wish, Babylon, and the Whitney Houston-biopic I Wanna Dance With Somebody going up against it. Cameron’s film could catch the same fever again and have legs to make it last into 2023.