Syracuse has been one of the surprises early on in the college football season with a 3-0 start including a pair of Power 5 victories after beating the Purdue Boilermakers at home in Week 4. Garrett Shrader threw three touchdown passes in the 32-29 win and has an 8:0 touchdown-to-interception ratio through the first three games of 2022. Coming off a disappointing showing against the Illinois Fighting Illini, Virginia needed a last-second field goal to knock off the Old Dominion Monarchs 16-14 last weekend, heading into the Cavaliers first conference game.
Syracuse is a 10-point favorite on DraftKings Sportsbook with -365 moneyline odds, making Virginia a +300 underdog. The over/under is set at 54.