Opening odds for No. 6 Iowa State vs. No. 11 Pittsburgh in 2023 NCAA Tournament

Update 11:45 p.m. ET: Pitt hung on for a comeback 60-59 win over Mississippi State to make the main field. Jamarius Burton’s pull-up jumper in the lane with six seconds left was the difference. Colgate transfer Nelly Cummings led all Panthers with 15 points, and the team as a whole was 9-19 from three-point range.

The No. 6 Iowa State Cyclones will face the No. 11 Pitt Panthers in the first round of the 2023 NCAA Tournament. We’re taking a look at the odds and lines on DraftKings Sportsbook.

The Cyclones started strong in Big 12 play, but got knocked around a bit in a tough conference before finishing off their season with a win over Baylor. Iowa State brings one of the country’s best defenses, allowing opponents to score just 62.2 points per game on average. However, their offense has not been up to the same level this season.

The Pittsburgh Panthers got smashed by the Duke Blue Devils the last time we saw them, but did enough to get into the NCAA Tournament for the first time since the 2015-16 season. Pitt is a significantly better offensive team than it is on the defensive end with Jamarius Burton and Blake Hinson both scoring more than 15 points per game.

2023 NCAA Tournament: No. 6 Iowa State vs. No. 11 Mississippi State/Pittsburgh odds

Spread: Iowa State -4.5
Over/Under: 133.5
Moneyline: ISU -190, Pitt +160