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Best NFL player prop bets for 49ers vs. Seahawks for Week 15 Thursday Night Football

We go over the lines on DraftKings Sportsbook and pick out our favorite player prop bets to consider for Week 15 Thursday Night Football.

Geno Smith #7 of the Seattle Seahawks gathers his teammates during the first quarter of the game against the Carolina Panthers at Lumen Field on December 11, 2022 in Seattle, Washington. Photo by Jane Gershovich/Getty Images

We have made it to Week 15 of the NFL season. This week’s iteration of Thursday Night Football will highlight the best of the NFC West as the San Francisco 49ers take on the Seattle Seahawks. Kickoff from Lumen Field in Seattle, Washington is set for 8:15 p.m. ET, and the game will air on Amazon Prime Video.

All odds come courtesy of DraftKings Sportsbook.

49ers vs. Seahawks: Best NFL player prop bets

Christian McCaffrey, over 78.5 rushing yards (-105)

McCaffrey has helped to turn around the 49ers' offense, as the team has yet to lose a game since he has been in town. He has played his role well, even if he hasn’t amassed the number of yards you typically expect from him. With the loss of wide receiver Deebo Samuel, McCaffrey should see his role expand. Seattle’s defense is giving up the second-most rushing yards per game, so McCaffrey should amass more than 78 rushing yards.

Brandon Aiyuk, over 50.5 receiving yards (-115)

Speaking of Samuel missing in action, this should open up the door for Brandon Aiyuk to be more involved in the offense. With Brock Purdy under center, Aiyuk had two receptions for 57 yards last week. He has at least 51 receiving yards in seven of his last nine games and should be able to make that eight on Thursday.

Kenneth Walker, under 49.5 rushing yards (-115)

Walker missed the Seahawks' last game with an injury but is expected to play Thursday night. He couldn’t have a worse matchup in his return. San Francisco’s defense is allowing the fewest rushing yards per game. Walker has had three straight games with fewer than 37 rushing yards, so look for the under in this one.