How to watch, what to watch for Eagles vs. 49ers in Week 4

The San Francisco 49ers and Philadelphia Eagles square off on Sunday Night Football this weekend to close out Week 4 Sunday. It’s safe to say network executives did not quite anticipate the matchup looking like it currently does.

The Eagles head west sitting at 0-2-1. They tied the Bengals in a game neither team seemed interested in winning late in overtime. Carson Wentz is struggling with accuracy and head coach Doug Pederson was actually asked if he was considering benching Wentz for rookie Jalen Hurts. Things aren’t pretty right now in Philly.

They face a 49ers squad decimated by injuries. Quarterback Jimmy Garoppolo, running backs Raheem Mostert and Tevin Coleman, cornerback Richard Sherman, and defensive linemen Nick Bosa and Solomon Thomas could all be absent on Sunday. Tight end George Kittle might return, but his status will be something to track heading into the weekend. The 49ers still thumped the Giants in Week 3 behind Nick Mullens and Jerick McKinnon.

TV Info

Date: Sunday, October 4
Time: 8:20 p.m. ET
Channel: NBC
Live stream: NBCSports.com/live

Notable Statistical rankings (Football Outsiders)

Eagles: 23rd vs. Pass, 16th vs. Rush
49ers: 7th vs. Pass, 7th vs. Rush

DraftKings Sportsbook odds

Eagles: +6.5, +215
49ers: -6.5, -275
Total: 45

Injury report

Eagles

OUT: WR DeSean Jackson (hamstring), WR Alshon Jeffery (foot), CB Avonte Maddox (ankle), CB Trevor Williams (rib), T Jason Peters (foot — to IR)

DOUBTFUL: WR J.J. Arcega-Whiteside (calf)

49ers

OUT: DE Dee Ford (back), QB Jimmy Garoppolo (ankle), LB Dre Greenlaw (quadricep), CB Emmanuel Moseley (concussion), RB Raheem Mostert (knee), TE Jordan Reed (knee), CB Ahkello Witherspoon (hamstring)

QUESTIONABLE: CB K’Waun Williams (hip)

Fantasy football start/sit advice

Eagles

Zach Ertz, TE, $5,300

If you have Ertz on your roster, you will start him most weeks. This week, he might even be worth a flex spot if you have another solid tight end. Fellow tight end Dallas Goedert will miss time with an ankle injury and wide receiver DeSean Jackson is dealing with a minor hamstring strain. There’s a lot of targets potentially available for Ertz, even if Alshon Jeffery gets healthy for this weekend.

Greg Ward, WR, $3,900

If Jackson does not play or is limited in Week 4, it opens the door for another opportunity for Ward. He led the team with eight receptions for 72 yards and a touchdown, and was tops with 11 targets. Jackson’s injury isn’t too serious, but given how those kinds of things can flare up, it’s worth tracking. Alshon Jeffery

49ers

Jerick McKinnon/Jeff Wilson, RB, $5,700/$4,900

McKinnon got the start and more snaps, but Wilson was the higher scoring fantasy back. Part of that came due to additional work when McKinnon injured his ribs. If McKinnon is active he’s the better start. If McKinnon is inactive, Wilson will be the start. If McKinnon is active but comes into the weekend as questionable, you might lean Wilson.

Brandon Aiyuk, WR, $5,000

The rookie impressed in his second career game, catching five passes for 70 yards and picking up 31 yards and a touchdown on the ground. He won’t do that every week, but with Deebo Samuel out and George Kittle possibly out, he might have some momentum on his side. And if he’s finding a connection with Nick Mullens, there’s some upside here.