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49ers vs. Giants: How to watch, what to watch in Week 3

The San Francisco 49ers and New York Giants face off in Week 3 of the 2020 NFL season. We break down how to watch the game, odds for the matchup, key injuries, and notable fantasy football start/sit considerations.

Jerick McKinnon #28 of the San Francisco 49ers carries the ball as John Franklin-Myers #91 of the New York Jets defends during the second half at MetLife Stadium on September 20, 2020 in East Rutherford, New Jersey. Photo by Sarah Stier/Getty Images

The New York Giants travel to San Francisco this week to take on the 49ers. The 49ers are coming off a solid 31-13 win over the Jets in week two. The win helped the 49ers get back to 1-1 on the year, but the numbers of injuries that hit Kyle Shanahan’s team left them reeling.

The Giants lost Saquon Barkley for the season to a brutal ACL tear in their loss to the Bears. New York is 0-2 on the season and desperate for something hopeful in their matchup with the 49ers.

Both teams have very different goals for the season, but both come into this week already depleted after two weeks of play. Each need some level of injury luck this week as they try to adapt to their respective new normals.

TV Info

Date: Sunday, September 27
Time: 1 p.m. ET
Channel: FOX
Broadcast map

Notable Statistical rankings (Football Outsiders)

49ers: 14th vs. Pass, 8th vs. Rush
Giants: 12th vs. Pass, 6th vs. Rush

DraftKings Sportsbook odds

49ers: -4, -195
Giants: +4, +165
Total: 41.5

Injury report


OUT: RB Tevin Coleman (knee), DE Dee Ford (back), QB Jimmy Garoppolo (ankle), LB Dre Greenlaw (quadricep), TE George Kittle (knee), RB Raheem Mostert (knee)

QUESTIONABLE: CB Ahkello Witherspoon (hamstring)


DOUBTFUL: S Adrian Colbert (quadricep)

QUESTIONABLE: CB Brandon Williams (groin)

Fantasy football start/sit advice


Nick Mullens, Quarterback, $5,100

You might be tempted to throw Nick Mullens a start this week. Don’t give in. Mullens is the assumed starter with Jimmy Garoppolo out with an ankle injury. Seeing how comfortable Mullens is with a quickly shifting 49ers offense is key, and you don’t want your fantasy team relying on it.


Dion Lewis, Running Back, $5,300

With the glaring absence of Saquon Barkley in the Giants backfield this week, Dion Lewis and Wayne Gallman will be the two competing for touches. Lewis feels like the man this week against a more vulnerable and injury riddled 49ers defense.

Giants, Defense, $2,700

Of all the weeks to get value out of the Giants defense, it’s this week. The 49ers are beat up and disheveled, ready to put up a dud of an offensive performance. The Giants did a solid job against the Bears and Steelers defensively in the first two weeks of the season, enough to justify a start.