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How to watch, what to watch for Cardinals vs. 49ers in Week 1

The Arizona Cardinals and San Francisco 49ers face off in Week 1 to open the 2020 NFL season. We break down how to watch the game, odds for the matchup, key injuries, and notable fantasy football start/sit considerations.

Quarterback Kyler Murray sets to take a snap from center A.Q. Shipley of the Arizona Cardinals in the game against the Los Angeles Rams at the Los Angeles Memorial Coliseum on December 29, 2019 in Los Angeles, California. Photo by Jayne Kamin-Oncea/Getty Images

The new-and-improved Arizona Cardinals are set to take on the San Francisco 49ers in Week 1 of the 2020 NFL season. The Cardinals are looking to take a big step forward now that Kyler Murray has been gifted a star receiver in DeAndre Hopkins, and they’ll be tested against a 49ers team that was won win away from a world championship last season.

Murray’s battle against one of the fiercest defensive lines in the NFL will be something to look out for, but so will San Francisco’s rushing attack. Whether Raheem Mostert can establish himself as a full-time feature back remains to be seen.

TV Info

Date: September 13
Time: 4:25 p.m. ET
Channel: FOX
Broadcast map

Notable Statistical rankings (Football Outsiders)

Cardinals (2019): 26th vs. Pass, 6th vs. Rush
49ers (2019): 2nd vs. Pass, 9th vs. Rush

DraftKings Sportsbook odds

Cardinals: +7, +255
49ers: -7, -335
Total: 47

Pick: Cardinals

I think the 49ers win this one, but the Cardinals gave them fits last season and they are a better team than last season. The addition of DeAndre Hopkins will add another dimension to their offense while Patrick Peterson will be ready to go to start the season this year. Their offensive line is still a problem, but they did improve it on paper. Seven points is just a bit too much for what has shown to be an interesting matchup the last two times.

Injury report



DNP: T Josh Jones (ankle)

Limited: WR Larry Fitzgerald (not injury related), WR DeAndre Hopkins (not injury related), TE Maxx Williams (ankle)


DNP: WR KeeSean Johnson (not injury related), T Josh Jones (ankle)

Limited: WR Larry Fitzgerald (not injury related), WR DeAndre Hopkins (not injury related), TE Maxx Williams (ankle)

Full: WR Larry Fitzgerald (not injury related), WR DeAndre Hopkins (not injury related)



DNP: WR Brandon Aiyuk (hamstring), WR Deebo Samuel (foot), CB Jason Verrett (hamstring)

Limited: C Ben Garland (ankle)


DNP: WR Deebo Samuel (foot), CB Jason Verrett (hamstring)

Limited: WR Brandon Aiyuk (hamstring), C Ben Garland (ankle)

Fantasy football start/sit advice


Kyler Murray, Quarterback, $6,400

Murray is the player with the highest ceiling in this matchup because of his athleticism. He was a top-notch fantasy quarterback without a dynamic WR1 and has that in Hopkins now. Arizona has great depth at wide receiver. Having a versatile running back like Kenyon Drake in the mix from the start of 2020 could help Murray become the top performer in the main slate.

DeAndre Hopkins, Wide receiver, $6,800

San Francisco fields one of the NFL’s better secondaries in 2019, but Hopkins has proven that he is one of the toughest covers in the world repeatedly. He torched the 49ers with 11 receptions for 149 yards and two scores in 2017 while Tom Savage and T.J. Yates under center, and I think he’ll give Richard Sherman and the 49ers’ other defensive backs a hard time.


Tevin Coleman, Running back, $4,200

I’m not sold on San Francisco committing to Mostert. It has too many talented backs and could need a change of pace against a team that excelled against the rush last season. Coleman could vulture some scores in short-yardage situations and is worth taking a flier on at this price.

George Kittle, Tight end, $7,200

It’s hard to justify skipping out on a player as productive as Kittle when San Francisco is dealing with injuries to Brandon Aiyuk and Deebo Samuels ahead of Week 1. He’s established himself as the 49ers’ best aerial threat and could become more of a focal point if important pass catchers aren’t healthy for the season debut,