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Here’s the Cardinals full schedule for the 2021 NFL Season

The NFL released the Arizona Cardinals schedule on Wednesday, May 12. We break it down, including a full list of games, prime time matchups, and strength of schedule.

NFL Over/Under | previewing NFL win totals for the 2021 season

The NFL announced the complete 2021 schedule on Wednesday, May 12, and the Arizona Cardinals are officially set to kick off their 2021 season September 12th against the Detroit Lions at 1 p.m. ET. Their first divisional game will be in Week 4 against the Seattle Seahawks at home.

The Cardinals upped their record in 2020 to 8-8 after going 5-10-1 the previous season, and 3-13 the season prior. But, after a strong 6-3 start, missing the playoffs was still a let down. This offseason, Arizona added DE J.J. Watt, WR A.J. Green, C Rodney Hudson and CB Malcolm Butler, but lost CB Patrick Peterson and LB Haason Reddick. The team spent its first round pick on Zaven Collins to pair with Isaiah Simmons on defense. We’ll see how those moves pay off, but all signs point to Kyler Murray and friends still competing for a playoff spot this season. If not, it will be a disappointment in the desert.

All times listed are Eastern.


Win total, over/under: O 8 (-120), U 8 (+107)
Division champs: +200

Prime time games

Week 8: TNF vs. Green Bay Packers
Week 14: MNF vs. Los Angeles Rams

Strength of schedule

Super Bowl odds: 32nd (toughest)
2021 win totals: 28th
2020 records: 19th

2021 Schedule

Week 1: Sep. 12 at Tennessee Titans 1:00 PM CBS
Week 2: Sep. 19 Minnesota Vikings 4:05 PM FOX
Week 3: Sep. 26 at Jacksonville Jaguars 1:00 PM FOX
Week 4: Oct. 3 at Los Angeles Rams 4:05 PM FOX
Week 5: Oct. 10 San Francisco 49ers 4:25 PM FOX
Week 6: Oct. 17 at Cleveland Browns 4:05 PM FOX
Week 7: Oct. 24 Houston Texans 1:25 PM CBS
Week 8: Oct. 2 Green Bay Packers (Thu) 8:20 PM FOX/NFLN/Amazon**
Week 9: Nov. 7 at San Francisco 49ers 4:25 PM FOX
Week 10: Nov. 14 Carolina Panthers 4:05 PM FOX
Week 11: Nov. 21 at Seattle Seahawks 4:25 PM FOX
Week 12: BYE
Week 13: Dec. 5 at Chicago Bears 1:00 PM FOX
Week 14: Dec. 13 Los Angeles Rams (Mon) 8:15 PM ESPN
Week 15: Dec. 19 at Detroit Lions 1:00 PM FOX
Week 16: Dec. 25 Indianapolis Colts 8:15 PM NFLN
Week 17: Jan. 2 at Dallas Cowboys 1:00 PM FOX
Week 18: Jan. 9 Seattle Seahawks 4:25 PM FOX

**NFL Network and Amazon simulcast subject to change