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2021 NFL Week 1 Best Bets

Pat Mayo gives his best bets for Week 1 of the NFL season.

Pat Mayo, Rob Pizzola and Cam Stewart give their 2021 NFL Week 1 Best Bets with their Gold, Silver and Bronze Selections of the Week. Plus, a recap of Thursday Night Football, Ravens running back news, and 2021 Fantasy Football Stock Watch for Ezekiel Elliott.

Week 1 Ranks, Injuries, Plays/Fades, Player Notes

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Week 1 — Rankings | Injuries | RB | WR | QB | TE | DST | Projections

Week 1 — Best Bets | Spread Picks | TNF DK Showdown | Start/Sit | Props

Week 1 DraftKings — DK Picks | Stacks | Optimizer | Obvious Picks

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How to Use DK Tools — Optimizer | Game Sims | Player vs Player Compare

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2021 NFL Week 1 Best Bets: Gold Picks

Mayo: Seattle Seahawks -2.5
Pizzola: Arizona Cardinals +3
Cam: Houston Texans +3

2021 NFL Week 1 Best Bets: Sliver Picks

Mayo: New York Jets vs. Carolina Panthers OVER 44.5
Pizzola: New York Jets +4
Cam: Arizona Cardinals +3

2021 NFL Week 1 Best Bets: Bronze Picks

Mayo: Alvin Kamara OVER 5.5 Receptions (+120)
Pizzola: Denver Broncos -3
Cam: Los Angeles Rams -8


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Pat Mayo is an award-winning video host and producer of long and short-form content, and the host of The Pat Mayo Experience daily talk show. (Subscribe for video or audio). Mayo (@ThePME) won the 2020 Fantasy Sports Writing Association Daily Fantasy Writer of the Year and Golf Writer of the Year awards, along with the Fantasy Sports Trade Association Best Sports Betting Analyst award, and was a finalist for four FSWA Awards in 2020 (Best Podcast, Best Video, Daily Fantasy Writer of the Year, Golf Writer of the Year). His 21 FSWA nominations lead all writers this decade and are third-most all-time. Mayo has been recognized across multiple sports (Football, Baseball & Golf), mediums (Video, Writing & Podcasting), genre (Humor), and game formats (Daily Fantasy and Traditions Season Long). Beyond sports, Mayo covers everything from entertainment to pop culture to politics. If you have a fantasy question, general inquiry or snarky comment, ship it to Mayo at ThePatMayoExperience@gmail.com and the best will be addressed on the show.


I am a promoter at DraftKings and am also an avid fan and user (my username is ThePME) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.


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